CD164 Gene Summary [Human]
This gene encodes a transmembrane sialomucin and cell adhesion molecule that regulates the proliferation, adhesion and migration of hematopoietic progenitor cells. The encoded protein also interacts with the C-X-C chemokine receptor type 4 and may regulate muscle development. Elevated expression of this gene has been observed in human patients with Sezary syndrome, a type of blood cancer, and a mutation in this gene may be associated with impaired hearing. [provided by RefSeq, Oct 2016]
Details
| Type | Retained Intron |
| Official Symbol | CD164 |
| Official Name | CD164 molecule [Source:HGNC Symbol;Acc:HGNC:1632] |
| Ensembl ID | ENSG00000135535 |
| Bio databases IDs | |
| Aliases | CD164 molecule, deafness, autosomal dominant 66 |
| Synonyms | A115, A24, CD164 antigen, CD164 molecule, DFNA66, Endolyn, MGC, MGC-24, MGC-24v, MSSP, MUC-24 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CD164 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Multi-glycosylated core protein 24 (MGC-24), sialomucin
- extracellular domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- Alzheimer disease
- severe acute respiratory syndrome
- androgenic alopecia
- lung carcinoma process
- clonal hematopoiesis
- autosomal dominant deafness type 66
- nonsyndromic autosomal dominant hearing impairment
- lung carcinoma
- infection by HIV-1
role in cell
- proliferation
- differentiation
- growth
- apoptosis
- adhesion
- viral entry in
- cell-cell adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- endosomes
- lysosome
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CD164 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle organ development
- immune response
- signal transduction
- hemopoiesis
- negative regulation of cell adhesion
- heterophilic cell-cell adhesion
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- endosome
- endosome membrane
- extracellular region
- plasma membrane
- lysosomal membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding