SCYL2 Gene Summary [Human]
The protein encoded by this gene associates with clathrin-coated complexes at the plasma membrane and with endocytic coated vesicles. The encoded protein phosphorylates the beta2 subunit of the plasma membrane adapter complex AP2 and interacts with clathrin, showing involvement in clathrin-dependent pathways between the trans-Golgi network and the endosomal system. In addition, this protein has a role in the Wnt signaling pathway by targeting frizzled 5 (Fzd5) for lysosomal degradation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]
Details
| Type | Protein Coding |
| Official Symbol | SCYL2 |
| Official Name | SCY1 like pseudokinase 2 [Source:HGNC Symbol;Acc:HGNC:19286] |
| Ensembl ID | ENSG00000136021 |
| Bio databases IDs | |
| Aliases | SCY1 like pseudokinase 2, coated vesicle-associated kinase of 104 kDa |
| Synonyms | AMC4, AMCNACC, AU015688, AW536445, CVAK104, D10Ertd802e, RGD1305665, SCY1-like 2 (S. cerevisiae), SCY1 like pseudokinase 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SCYL2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- protein binding
- receptor binding
- Protein kinase domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neurogenic arthrogryposis multiplex congenita 4 with agenesis of the corpus callosum
- growth failure
- preeclampsia
- hereditary disorder
role in cell
- growth
- loss in
- signaling in
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SCYL2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- clathrin-mediated endocytosis
- endosome to lysosome transport
- brain development
- pyramidal neuron development
- receptor internalization
Cellular Component
Where in the cell the gene product is active
- endosome membrane
- Golgi apparatus
- clathrin-coated vesicle
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein kinase activity
- receptor binding