Scyl2 Gene Summary [Rat]
Predicted to enable signaling receptor binding activity. Predicted to be involved in endosome to lysosome transport; pyramidal neuron development; and receptor-mediated endocytosis. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita-4. Orthologous to human SCYL2 (SCY1 like pseudokinase 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Scyl2 |
| Official Name | SCY1 like pseudokinase 2 [Source:RGD Symbol;Acc:1305665] |
| Ensembl ID | ENSRNOG00000024955 |
| Bio databases IDs | |
| Aliases | SCY1 like pseudokinase 2 |
| Synonyms | AMC4, AMCNACC, AU015688, AW536445, CVAK104, D10Ertd802e, RGD1305665, SCY1-like 2 (S. cerevisiae), SCY1 like pseudokinase 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Scyl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- protein binding
- receptor binding
- Protein kinase domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neurogenic arthrogryposis multiplex congenita 4 with agenesis of the corpus callosum
- growth failure
- preeclampsia
- hereditary disorder
role in cell
- growth
- loss in
- signaling in
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Scyl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- clathrin-mediated endocytosis
- endosome to lysosome transport
- brain development
- pyramidal neuron development
- receptor internalization
Cellular Component
Where in the cell the gene product is active
- endosome membrane
- Golgi apparatus
- clathrin-coated vesicle
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein kinase activity
- receptor binding