Rcbtb2 Gene Summary [Mouse]
Acts upstream of or within several processes, including digestive tract development; hematopoietic or lymphoid organ development; and liver development. Located in acrosomal vesicle. Used to study malignant histiocytic disease. Orthologous to human RCBTB2 (RCC1 and BTB domain containing protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rcbtb2 |
| Official Name | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 [Source:MGI Symbol;Acc:MGI:1917200] |
| Ensembl ID | ENSMUSG00000022106 |
| Bio databases IDs | |
| Aliases | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 |
| Synonyms | 2610028E02Rik, 2810420M18Rik, CHC1L, RC/BTB2, RCC1 and BTB domain containing protein 2, RCC1-LIKE G EXCHANGING FACTOR RLG, regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2, RLG |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rcbtb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Regulator of chromosome condensation (RCC1) repeat
- Broad-Complex, Tramtrack and Bric a brac
- guanyl-nucleotide exchange factor
- BTB_POZ
- BTB/POZ domain
- protein binding
- BACK (BTB and C-terminal Kelch) domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- diabetes mellitus
- neoplastic histiocytosis
- hematologic cancer
- hematological neoplasia
- lymphomagenesis
- prostate cancer
- gastrointestinal neoplasia
- lymphoid cancer
role in cell
- function
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- acrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rcbtb2 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- acrosomal vesicle
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity