TSNAX Gene Summary [Human]
This gene encodes a protein which specifically interacts with translin, a DNA-binding protein that binds consensus sequences at breakpoint junctions of chromosomal translocations. The encoded protein contains bipartite nuclear targeting sequences that may provide nuclear transport for translin, which lacks any nuclear targeting motifs. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TSNAX |
| Official Name | translin associated factor X [Source:HGNC Symbol;Acc:HGNC:12380] |
| Ensembl ID | ENSG00000116918 |
| Bio databases IDs | |
| Aliases | translin associated factor X |
| Synonyms | C3PO, DISC1, LOC100039215, translin-associated factor X, TRAX |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TSNAX often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Translin family
- NDEL1 binding domain
- Translin and translin-associated factor-X (TRAX)
- binding protein
- self-association domain
- single-stranded DNA binding
- G-protein-coupled receptor binding
- protein binding
- sequence-specific DNA binding
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neonatal late-onset sepsis
role in cell
- expression in
- production in
- growth
- migration
- stiffness
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TSNAX gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- posttranscriptional gene silencing by RNA
- spermatogenesis
- cell differentiation
- production of siRNA involved in RNA interference
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- Golgi apparatus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- RNA binding
- metal ion binding
- sequence-specific DNA binding
- single-stranded DNA binding
- A2A adenosine receptor binding
- endoribonuclease activity