Aldob Gene Summary [Mouse]
This gene encodes a subunit of the homotetrameric enzyme aldolase B, an isozyme of the class I fructose 1,6-bisphosphate aldolase enzyme. This enzyme catalyzes the conversion of fructose 1,6-bisphosphate to dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. Homozygous knockout mice for this gene exhibit liver damage and death following fructose ingestion. A pseudogene of this gene has been identified in the genome. [provided by RefSeq, Aug 2015]
Details
| Type | Protein Coding |
| Official Symbol | Aldob |
| Official Name | aldolase B, fructose-bisphosphate [Source:MGI Symbol;Acc:MGI:87995] |
| Ensembl ID | ENSMUSG00000028307 |
| Bio databases IDs | |
| Aliases | aldolase B, fructose-bisphosphate |
| Synonyms | ALDB, ALDO2, aldolase B, fructose-bisphosphate, aldolase, fructose-bisphosphate B, Fructose Bisphosphatase Aldolase B, Fructose bisphosphate aldolase b, LIV10 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Aldob often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- ATPase binding
- binding protein
- monosaccharide binding
- cytoskeletal protein binding
- TIM-like beta/alpha barrel domains
- Fructose-bisphosphate aldolase class-I
- fructose-bisphosphate aldolase
- enzyme
- protein binding
- fructose-1-phosphate aldolase activity
- identical protein binding
Pathways
Biological processes and signaling networks where the Aldob gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- diabetes mellitus
- fibrosis
- diabetic nephropathy
- cancer
- epithelial cancer
- liver cancer
- fructose intolerance
- colon epithelial cancer
- chromophobe renal cell carcinoma
role in cell
- formation in
- binding
- glycolysis in
- O-GlcNAcylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- centrosome
- microtubule organizing centers
- cytosol
- smooth endoplasmatic reticulum
- rough endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Aldob gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- gluconeogenesis
- vacuolar proton-transporting V-type ATPase complex assembly
- positive regulation of ATPase activity
- glycolysis
- fructose metabolic process
- NADH oxidation
- fructose 1,6-bisphosphate metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- microtubule organizing center
- centriolar satellite
- cytosol
Molecular Function
What the gene product does at the molecular level
- fructose binding
- identical protein binding
- protein binding
- cytoskeletal protein binding
- fructose-bisphosphate aldolase activity
- ATPase binding
- binding, bridging