POLR1E Gene Summary [Human]
Predicted to enable DNA binding activity; DNA-directed 5'-3' RNA polymerase activity; and RNA polymerase I general transcription initiation factor binding activity. Involved in nucleolar large rRNA transcription by RNA polymerase I. Located in fibrillar center and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | POLR1E |
| Official Name | RNA polymerase I subunit E [Source:HGNC Symbol;Acc:HGNC:17631] |
| Ensembl ID | ENSG00000137054 |
| Bio databases IDs | |
| Aliases | RNA polymerase I subunit E, RNA polymerase I associated factor 53 |
| Synonyms | A49, AU042259, D030019D19Rik, PAF53, polymerase (RNA) I polypeptide E, PRAF1, RGD1565773, RNA polymerase I subunit E, RPA49 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human POLR1E often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- A49-like RNA polymerase I associated factor
- transcription factor binding
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the POLR1E gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- fibrillar center
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human POLR1E gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA polymerase I transcriptional preinitiation complex assembly
- transcription initiation from RNA polymerase I promoter
- transcription elongation from RNA polymerase I promoter
- transcription of nuclear large rRNA transcript from RNA polymerase I promoter
Cellular Component
Where in the cell the gene product is active
- DNA-directed RNA polymerase I complex
- nucleolus
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- RNA polymerase I transcription factor binding