NOC2L Gene Summary [Human]
Histone modification by histone acetyltransferases (HAT) and histone deacetylases (HDAC) can control major aspects of transcriptional regulation. NOC2L represents a novel HDAC-independent inhibitor of histone acetyltransferase (INHAT) (Hublitz et al., 2005 [PubMed 16322561]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | NOC2L |
| Official Name | NOC2 like nucleolar associated transcriptional repressor [Source:HGNC Symbol;Acc:HGNC:24517] |
| Ensembl ID | ENSG00000188976 |
| Bio databases IDs | |
| Aliases | NOC2 like nucleolar associated transcriptional repressor, novel INHAT repressor, protein phosphatase 1, regulatory subunit 12 |
| Synonyms | AF155546, Gm3811, Inhibitor of histone deacetyltransferase, NET15, NET7, NIR, NOC2-like nucleolar associated transcriptional repressor, PPP1R112, RGD1309387 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NOC2L often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- transcription regulator
- binding protein
- Noc2p family
- transcription co-repressor
- transcription factor binding
- chromatin binding
- p53 binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- preeclampsia
- pancreatic carcinoma
- pancreatic epithelial cancer
role in cell
- expression in
- apoptosis
- proliferation
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cytosol
- chromosome
- nucleosomes
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NOC2L gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of gene expression, epigenetic
- ribosomal large subunit biogenesis
- apoptotic process
- cellular response to UV
- negative regulation of B cell apoptotic process
- negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- Noc2p-Noc3p complex
- Noc1p-Noc2p complex
- cytosol
- chromosome
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- transcription corepressor activity
- histone binding
- nucleosome binding
- chromatin binding