POLR2D Gene Summary [Human]
This gene encodes the fourth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit is associated with the polymerase under suboptimal growth conditions and may have a stress protective role. A sequence for a ribosomal pseudogene is contained within the 3' untranslated region of the transcript from this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | POLR2D |
| Official Name | RNA polymerase II subunit D [Source:HGNC Symbol;Acc:HGNC:9191] |
| Ensembl ID | ENSG00000144231 |
| Bio databases IDs | |
| Aliases | RNA polymerase II subunit D, RNA polymerase II subunit hsRPB4 |
| Synonyms | 2310002G05Rik, 2610028L19RIK, HSRBP4, HSRPB4, polymerase (RNA) II (DNA directed) polypeptide D, RBP4, RNA polymerase II subunit D, RPB16, RPB4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human POLR2D often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNA-directed RNA-polymerase II subunit
- DNA-directed RNA polymerase
- RNA polymerase Rpb4
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the POLR2D gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human POLR2D gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription from RNA polymerase II promoter
- transcription initiation from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- cytosol
- DNA-directed RNA polymerase II, core complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- nucleotide binding
- protein binding
- translation initiation factor binding