TMEM8B Gene Summary [Human]
Involved in cell-matrix adhesion. Located in cell surface and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TMEM8B |
| Official Name | transmembrane protein 8B [Source:HGNC Symbol;Acc:HGNC:21427] |
| Ensembl ID | ENSG00000137103 |
| Bio databases IDs | |
| Aliases | transmembrane protein 8B, nasopharyngeal carcinoma expressed 6 |
| Synonyms | 4930500O05Rik, C9orf127, FP588, LINC00950, NAG-5, NGX6, RGD1310012, transmembrane protein 8B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TMEM8B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein of unknown function (DUF3522)
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- nasopharyngeal cancer
- nasopharyngeal carcinoma
- epithelial cancer
- colorectal carcinomagenesis
- colorectal carcinoma
- plexiform neurofibroma
role in cell
- migration
- expression in
- adhesion
- invasion by
- mitosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TMEM8B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- regulation of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrion
- endoplasmic reticulum
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding