TRAF3 Gene Summary [Human]
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. The protein also plays a role in the regulation of antiviral response. Mutations in this are associated with Encephalopathy, acute, infection-induced, herpes-specific 5. [provided by RefSeq, Jul 2020]
Details
| Type | Protein Coding |
| Official Symbol | TRAF3 |
| Official Name | TNF receptor associated factor 3 [Source:HGNC Symbol;Acc:HGNC:12033] |
| Ensembl ID | ENSG00000131323 |
| Bio databases IDs | |
| Aliases | TNF receptor associated factor 3 |
| Synonyms | amn, CAP-1, CD40bp, CD40RR ASSOCIATED FACTOR, CRAF1, IIAE5, LAP1, RNF118, T-BAM, TNF receptor-associated factor 3, Trafamn |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRAF3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- homo-oligomerization domain
- TRADD binding domain
- coiled-coil domain
- enzyme
- isoleucine zipper domain
- identical protein binding
- TRAF-type zinc finger
- receptor binding domain
- TRAF binding domain
- Ras-binding domain
- Ring finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- carboxy-terminal activation region
- zinc-RING finger domain
- ubiquitin protein ligase binding
- protein kinase binding
- MATH
- tumor necrosis factor receptor binding
- catalytic domain
- ubiquitin protein ligase activity
- protein phosphatase binding
- TRAF-N subdomain
- enzyme binding
- protein binding
- TRAF domain
- SynN
- ubiquitin-protein transferase activity
- transmembrane domain
- zinc finger domain
- TRAF-C subdomain
- Zinc finger, C3HC4 type (RING finger)
Pathways
Biological processes and signaling networks where the TRAF3 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Activation of IRF by Cytosolic Pattern Recognition Receptors
- Altered T Cell and B Cell Signaling in Rheumatoid Arthritis
- April Mediated Signaling
- Autophagy
- B Cell Activating Factor Signaling
- CD40 Signaling
- Lymphotoxin β Receptor Signaling
- Neuroinflammation Signaling Pathway
- NF-κB Signaling
- OX40 Signaling Pathway
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of PKR in Interferon Induction and Antiviral Response
- Role of RIG1-like Receptors in Antiviral Innate Immunity
- Small Cell Lung Cancer Signaling
- TWEAK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- plasma cell myeloma
- schizophrenia
- major depression
- acne
- multiple sclerosis
- epithelial cancer
- hyperplasia
- lymphadenopathy
- COVID-19
role in cell
- proliferation
- migration
- quantity
- phosphorylation in
- activation in
- production in
- morphology
- expression in
- apoptosis
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent-insoluble membrane fraction
- soluble fraction
- membrane fraction
- cytoskeleton
- perinuclear region
- Nucleus
- Plasma Membrane
- endosomes
- Mitochondria
- cytosol
- cytoplasmic face of plasma membrane
- endosomal membrane
- membrane rafts
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRAF3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Toll signaling pathway
- signal transduction
- negative regulation of NF-kappaB transcription factor activity
- positive regulation of type I interferon production
- toll-like receptor 4 signaling pathway
- regulation of proteolysis
- regulation of I-kappaB kinase/NF-kappaB cascade
- regulation of apoptotic process
- type I interferon-mediated signaling pathway
- toll-like receptor signaling pathway
- tumor necrosis factor-mediated signaling pathway
- regulation of interferon-beta production
- apoptotic process
- defense response to virus
- protein K63-linked ubiquitination
- regulation of cytokine production
- TRIF-dependent toll-like receptor signaling pathway
- regulation of defense response to virus
Cellular Component
Where in the cell the gene product is active
- endosome
- ubiquitin ligase complex
- cytoplasm
- mitochondrion
- cytosol
- endosome membrane
- CD40 receptor complex
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- ubiquitin-protein ligase activity
- zinc ion binding
- identical protein binding
- protein binding
- protein phosphatase binding
- ubiquitin protein ligase binding
- tumor necrosis factor receptor binding
- thioesterase binding