FOXF2 Gene Summary [Human]
FOXF2 encodes forkhead box F2, one of many human homologues of the Drosophila melanogaster transcription factor forkhead. FOXF2 is expressed in lung and placenta, and has been shown to transcriptionally activate several lung-specific genes. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | FOXF2 |
| Official Name | forkhead box F2 [Source:HGNC Symbol;Acc:HGNC:3810] |
| Ensembl ID | ENSG00000137273 |
| Bio databases IDs | |
| Aliases | forkhead box F2 |
| Synonyms | Fkh20, FKHL6, Forkhead box F2, FREAC-2, LUN |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FOXF2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- FH_FOX
- nucleic acid binding
- transcription factor binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- Forkhead domain
- FORKHEAD
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- metastasis
- epithelial neoplasia
- neoplasia
- adenoma formation
- benign neoplasia
- hypoplasia
- palatal shelves fail to meet at midline
- gastric cancer
- amyotrophic lateral sclerosis
role in cell
- expression in
- apoptosis
- proliferation
- number
- phosphorylation in
- migration
- epirubicin resistance
- organization
- invasion by
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- nucleoplasm
- nuclear bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FOXF2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- genitalia development
- palate development
- positive regulation of transcription from RNA polymerase II promoter
- establishment of planar polarity of embryonic epithelium
- regulation of transcription from RNA polymerase II promoter
- organ morphogenesis
- negative regulation of transcription, DNA-dependent
- embryonic digestive tract development
- positive regulation of transcription, DNA-dependent
- embryonic camera-type eye morphogenesis
- extracellular matrix organization
- epithelial to mesenchymal transition
- regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- nuclear body
- intracellular membrane-bounded organelle
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- TFIIB-class transcription factor binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity