DNTTIP1 Gene Summary [Human]
DNTTIP1 binds DNA and enhances the activity of terminal deoxynucleotidyltransferase (TDT, or DNTT; MIM 187410), a DNA polymerase that catalyzes the polymerization of DNA in the absence of a DNA template (Yamashita et al., 2001 [PubMed 11473582]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | DNTTIP1 |
| Official Name | deoxynucleotidyltransferase terminal interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:16160] |
| Ensembl ID | ENSG00000101457 |
| Bio databases IDs | |
| Aliases | deoxynucleotidyltransferase terminal interacting protein 1, novel protein similar to synaptotagmin 1 (SYT1, P65) (isoform 1), TdT binding protein |
| Synonyms | 6430706C13Rik, C20orf167, deoxynucleotidyltransferase terminal interacting protein 1, deoxynucleotidyltransferase, terminal, interacting protein 1, dJ447F3.4, P65, Tdif1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DNTTIP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ribonucleoprotein binding domain
- RGG domain
- binding protein
- DNTTIP1 dimerization domain
- ligand-dependent nuclear receptor
- protein homodimerization
- chromatin binding
- protein binding
- enzyme activator activity
- glutamine serine tyrosine-rich domain
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- chromosome
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DNTTIP1 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- nucleus
- histone deacetylase complex
- chromosome
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- protein homodimerization activity
- nucleosome binding