TRIM33 Gene Summary [Human]
The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact with this protein have not yet been identified. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TRIM33 |
| Official Name | tripartite motif containing 33 [Source:HGNC Symbol;Acc:HGNC:16290] |
| Ensembl ID | ENSG00000197323 |
| Bio databases IDs | |
| Aliases | tripartite motif containing 33, transcriptional intermediary factor 1 gamma, ret-fused gene 7 |
| Synonyms | 8030451N04RIK, ECTO, ECTODERMIN, PTC7, RFG7, TF1G, TIF1G, TIF1GAMMA, Tif1 γ, TIFGAMMA, tripartite motif-containing 33 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRIM33 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins
- SMAD binding
- PHD zinc finger
- transcription regulator
- protein kinase
- B-Box C-terminal domain
- ubiquitin protein ligase activity
- TIF1 signature sequence
- chromatin binding
- protein binding
- Bromodomain
- B-box-type zinc finger superfamily
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- B-box zinc finger
- PHD finger superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- liver cancer
- metastasis
- hepatic fibrosis
- non-small cell lung cancer
- autism
- tumorigenesis
- non-small cell lung carcinoma
- congenital dislocation of hip
- growth failure
role in cell
- survival
- expression in
- proliferation
- growth
- phosphorylation in
- activation in
- accumulation
- invasion by
- cytostasis
- epithelial-mesenchymal transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- PML nuclear bodies
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRIM33 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of BMP signaling pathway
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- regulation of transforming growth factor beta receptor signaling pathway
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- ubiquitin-protein ligase activity
- zinc ion binding
- protein binding
- R-SMAD binding
- co-SMAD binding