TRIM10 Gene Summary [Human]
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic bodies. Studies in mice suggest that this protein plays a role in terminal differentiation of erythroid cells. Alternate splicing of this gene generates two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TRIM10 |
| Official Name | tripartite motif containing 10 [Source:HGNC Symbol;Acc:HGNC:10072] |
| Ensembl ID | ENSG00000137394 |
| Bio databases IDs | |
| Aliases | tripartite motif containing 10 |
| Synonyms | HERF1, RFB30, RNF9, tripartite motif-containing 10 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRIM10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- B-box-type zinc finger superfamily
- SPRY domain
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- zinc finger of C3HC4-type, RING
- Ring finger
- B-box zinc finger
- Ring finger domain
- protein binding
- associated with SPRY domains
- SPRY-associated domain
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- systemic juvenile idiopathic arthritis
- immune thrombocytopenia
- schizophrenia
- colon cancer
- human immunodeficiency virus I infection
role in cell
- expression in
- apoptosis
- production in
- differentiation
- splicing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRIM10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- erythrocyte differentiation
- negative regulation of viral entry into host cell
- innate immune response
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding