Trim10 Gene Summary [Mouse]
Predicted to enable ubiquitin protein ligase activity. Involved in host-mediated suppression of symbiont invasion. Acts upstream of or within erythrocyte differentiation. Located in cytoplasm. Is expressed in several structures, including central nervous system; immune system; liver; and ureter. Orthologous to human TRIM10 (tripartite motif containing 10). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trim10 |
| Official Name | tripartite motif-containing 10 [Source:MGI Symbol;Acc:MGI:1338757] |
| Ensembl ID | ENSMUSG00000073400 |
| Bio databases IDs | |
| Aliases | tripartite motif-containing 10 |
| Synonyms | HERF1, RFB30, RNF9, tripartite motif-containing 10 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trim10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- B-box-type zinc finger superfamily
- SPRY domain
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- zinc finger of C3HC4-type, RING
- Ring finger
- B-box zinc finger
- Ring finger domain
- protein binding
- associated with SPRY domains
- SPRY-associated domain
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- systemic juvenile idiopathic arthritis
- immune thrombocytopenia
- schizophrenia
- colon cancer
- human immunodeficiency virus I infection
role in cell
- expression in
- apoptosis
- production in
- differentiation
- splicing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trim10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- erythrocyte differentiation
- negative regulation of viral entry into host cell
- innate immune response
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding