PARP9 Gene Summary [Human]
Enables several functions, including ADP-D-ribose binding activity; NAD+ ADP-ribosyltransferase activity; and STAT family protein binding activity. Involved in several processes, including positive regulation of nitrogen compound metabolic process; regulation of defense response; and regulation of gene expression. Located in several cellular components, including mitochondrion; nucleoplasm; and site of DNA damage. Part of protein-containing complex. Colocalizes with nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PARP9 |
| Official Name | poly(ADP-ribose) polymerase family member 9 [Source:HGNC Symbol;Acc:HGNC:24118] |
| Ensembl ID | ENSG00000138496 |
| Bio databases IDs | |
| Aliases | poly(ADP-ribose) polymerase family member 9 |
| Synonyms | ARTD9, Bagl, BAL, BAL1, MGC:7868, poly (ADP-ribose) polymerase family, member 9, poly(ADP-ribose) polymerase family member 9, RGD1307534 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PARP9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- NAD ADP-ribosyltransferase
- macrodomain superfamily
- transcription co-repressor
- enzyme inhibitor activity
- enzyme binding
- transcription factor binding
- enzyme
- protein binding
- ADP_ribosyl
- macro domain
- binding protein
- pentosyltransferase
Pathways
Biological processes and signaling networks where the PARP9 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung cancer
- acute myeloid leukemia
- COVID-19
- antineutrophil cytoplasmic antibody-associated vasculitis
- Huntington disease
- psoriasis
- early missed abortion
- systemic lupus erythematosus
- systemic sclerosis
- Parkinson disease
role in cell
- phosphorylation in
- expression in
- production in
- binding
- accumulation in
- binding in
- migration
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Mitochondria
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PARP9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of response to interferon-gamma
- positive regulation of protein localization to nucleus
- positive regulation of chromatin binding
- positive regulation of tyrosine phosphorylation of STAT protein
- positive regulation of defense response to virus by host
- positive regulation of interferon-gamma-mediated signaling pathway
- double-strand break repair
- posttranscriptional regulation of gene expression
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of gene expression
- viral protein processing
- DNA damage checkpoint
- negative regulation of catalytic activity
- positive regulation of transcription, DNA-dependent
- innate immune response
- defense response to virus
- protein poly-ADP-ribosylation
- NAD biosynthesis via nicotinamide riboside salvage pathway
- cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- membrane
- mitochondrion
- cytosol
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ADP-D-ribose binding
- nucleotidyltransferase activity
- protein binding
- enzyme inhibitor activity
- histone binding
- transcription corepressor activity
- small conjugating protein ligase binding
- NAD+ binding
- enzyme binding
- NAD+ ADP-ribosyltransferase activity