DTX3L Gene Summary [Human]
Enables several functions, including STAT family protein binding activity; ubiquitin-like protein ligase binding activity; and ubiquitin-protein transferase activity. Involved in several processes, including positive regulation of macromolecule metabolic process; positive regulation of protein localization; and protein ubiquitination. Located in cytosol; lysosome; and nucleoplasm. Part of protein-containing complex. Colocalizes with early endosome and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | DTX3L |
| Official Name | deltex E3 ubiquitin ligase 3L [Source:HGNC Symbol;Acc:HGNC:30323] |
| Ensembl ID | ENSG00000163840 |
| Bio databases IDs | |
| Aliases | deltex E3 ubiquitin ligase 3L, rhysin 2 |
| Synonyms | BBAP, deltex 3-like, E3 ubiquitin ligase, deltex E3 ubiquitin ligase 3L, LOC151636, RGD1565144, RNF143 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DTX3L often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- RNA recognition motif (RRM) superfamily
- ubiquitin protein ligase activity
- protein binding activity, bridging
- enzyme inhibitor activity
- enzyme binding
- transcription factor binding
- enzyme
- Ring finger domain
- protein binding
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- Domain found at the C-terminus of deltex-like
- RING-H2 zinc finger domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- ZMYM2-FGFR1 induced stem cell leukemia lymphoma syndrome
- Huntington disease
role in cell
- binding
- molecular cleavage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- lysosome
- cytosol
- nucleoplasm
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DTX3L gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein localization to nucleus
- positive regulation of protein binding
- positive regulation of chromatin binding
- protein K48-linked ubiquitination
- protein transport
- endosome to lysosome transport
- positive regulation of defense response to virus by host
- double-strand break repair
- ubiquitin-dependent protein catabolic process
- negative regulation of ubiquitin-protein ligase activity
- DNA damage checkpoint
- Notch signaling pathway
- positive regulation of receptor catabolic process
- positive regulation of transcription, DNA-dependent
- innate immune response
- defense response to virus
- protein autoubiquitination
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- nucleus
- early endosome
- cytoplasm
- cytosol
- macromolecular complex
- lysosomal membrane
- lysosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- enzyme inhibitor activity
- histone binding
- metal ion binding
- small conjugating protein ligase binding
- enzyme binding