PPCDC Gene Summary [Human]
Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCDC (EC 4.1.1.36), one of the last enzymes in this pathway, converts phosphopantothenoylcysteine to 4-prime-phosphopantetheine (Daugherty et al., 2002 [PubMed 11923312]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | PPCDC |
| Official Name | phosphopantothenoylcysteine decarboxylase [Source:HGNC Symbol;Acc:HGNC:28107] |
| Ensembl ID | ENSG00000138621 |
| Bio databases IDs | |
| Aliases | phosphopantothenoylcysteine decarboxylase |
| Synonyms | 1810057I13RIK, 8430432M10RIK, coaC, MDS018, NEWGENE 1306267, phosphopantothenoylcysteine decarboxylase, RGD1306267 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPCDC often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphopantothenoylcysteine decarboxylase
- flavoprotein
- phosphopantothenoylcysteine decarboxylase, streptococcal
- FMN binding
- enzyme
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPCDC gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- coenzyme A biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cytosol
- phosphopantothenoylcysteine decarboxylase complex
Molecular Function
What the gene product does at the molecular level
- phosphopantothenoylcysteine decarboxylase activity
- identical protein binding
- protein binding
- FMN binding