DBI Gene Summary [Human]
This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | DBI |
| Official Name | diazepam binding inhibitor, acyl-CoA binding protein [Source:HGNC Symbol;Acc:HGNC:2690] |
| Ensembl ID | ENSG00000155368 |
| Bio databases IDs | |
| Aliases | diazepam binding inhibitor, acyl-CoA binding protein, endozepine |
| Synonyms | ACABP, ACBD1, ACBP, Acoabp3, ACYL-COA binding, CCK-RP, diazepam binding inhibitor, diazepam binding inhibitor, acyl-CoA binding protein, endozepine, EP, Homolog to endozepine-related protein precursor, Lcrf, LOC100365425, LOC679040, Odn, RNACOABP3, Ttn |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DBI often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- acyl-CoA binding
- protein binding
- identical protein binding
- benzodiazepine receptor binding
- ACBP
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- amyotrophic lateral sclerosis
- alopecia
- Alzheimer disease
- growth failure
- oxygen-induced retinopathy
- heroin dependence
- proliferative diabetic retinopathy
- colon epithelial cancer
- anxiety disorders with panic attacks
- colon carcinoma
role in cell
- proliferation
- expression in
- production in
- number
- mitogenesis
- formation in
- hypertrophy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- perinuclear region
- cellular membrane
- Nucleus
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- apical cytoplasm
- reticular perinuclear compartment
- endoplasmic reticulum lumen
- Golgi membrane
- mitochondrial outer membrane
- nucleoplasm
- synaptic vesicles
- myofibrils
- rough endoplasmatic reticulum
- peroxisomes
- membrane processes
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DBI gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of phospholipid transport
- phosphatidylcholine acyl-chain remodeling
- fatty acid metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular vesicular exosome
- protein-lipid complex
- endoplasmic reticulum
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- fatty-acyl-CoA binding
- long-chain fatty acyl-CoA binding
- benzodiazepine receptor binding