DYNC1LI1 Gene Summary [Human]
The protein encoded by this gene belongs to light intermediate subunit family, whose members are components of the multiprotein cytoplasmic dynein complex, which is involved in intracellular trafficking and chromosome segregation during mitosis. The protein plays a role in moving the spindle assembly checkpoint (SAC) from kinetochores to spindle poles. The protein may also mediate binding to other cargo molecules to facilitate intracellular vesicle trafficking. [provided by RefSeq, Jul 2016]
Details
| Type | Protein Coding |
| Official Symbol | DYNC1LI1 |
| Official Name | dynein cytoplasmic 1 light intermediate chain 1 [Source:HGNC Symbol;Acc:HGNC:18745] |
| Ensembl ID | ENSG00000144635 |
| Bio databases IDs | |
| Aliases | dynein cytoplasmic 1 light intermediate chain 1 |
| Synonyms | 1110053F02RIK, DC1L1, DLC-A, DLIC-1, DNCLI1, Dnclic1, dynein cytoplasmic 1 light intermediate chain 1, Dynein, cytoplasmic, light intermediate chain 1, LIC-1, LOC102546889 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DYNC1LI1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GDP binding
- Dynein light intermediate chain (DLIC)
- protein binding activity, bridging
- dynein heavy chain binding
- protein binding
- identical protein binding
- microtubule motor protein
Pathways
Biological processes and signaling networks where the DYNC1LI1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- Hexon
- DYNC1LI1
role in cell
- formation
- formation in
- development
- movement
- dispersal
- movement by
- stability
- checkpoint control
- dispersal in
- cohesion in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endocytic vesicle membrane
- Plasma Membrane
- centrosome
- secretory granule membrane
- cytosol
- Golgi membrane
- spindle pole
- synaptic vesicles
- late endosomes
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DYNC1LI1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- positive regulation of mitotic cell cycle spindle assembly checkpoint
- microtubule cytoskeleton organization
- regulation of vesicle-mediated transport
- microtubule-based movement
Cellular Component
Where in the cell the gene product is active
- secretory granule membrane
- centrosome
- cytoplasmic dynein complex
- membrane
- spindle pole
- cytosol
- kinetochore
- recycling endosome membrane
- plasma membrane
- endocytic vesicle membrane
- microtubule
Molecular Function
What the gene product does at the molecular level
- GTP binding
- ATP binding
- protein binding
- RNA binding
- GDP binding
- dynein heavy chain binding
- protein binding, bridging
- binding, bridging