Gcnt3 Gene Summary [Mouse]
Enables acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity. Acts upstream of or within intestinal absorption; kidney morphogenesis; and tissue morphogenesis. Predicted to be located in Golgi membrane. Orthologous to human GCNT3 (glucosaminyl (N-acetyl) transferase 3, mucin type). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gcnt3 |
| Official Name | glucosaminyl (N-acetyl) transferase 3, mucin type [Source:MGI Symbol;Acc:MGI:1919327] |
| Ensembl ID | ENSMUSG00000032226 |
| Bio databases IDs | |
| Aliases | glucosaminyl (N-acetyl) transferase 3, mucin type |
| Synonyms | 2010013H22RIK, 2210021I22RIK, 2210401J11RIK, C24GNT, C2/4GnT, C2GNT2, C2GNTM, DI/C2/C4GNT, dIGnT, glucosaminyl (N-acetyl) transferase 3, mucin type, GNTM |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gcnt3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Core-2/I-Branching enzyme
- acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
- N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase
- beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
- acetylglucosaminyltransferase
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- colitis
regulates
- Ighg2b
- core 2 O-glycans
- IgA
- core 4 O-glycan
- Immunoglobulin
- core 2 oligosaccharide
- O-glycan
- IgG2b
- I-branching core 1 O-glycan
- IgG1
role in cell
- proliferation
- sphere formation
- apigenin sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gcnt3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- intestinal absorption
- tissue morphogenesis
- kidney morphogenesis
- protein O-linked glycosylation
- O-glycan processing
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity
- acetylglucosaminyltransferase activity
- beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity