NOL3 Gene Summary [Human]
This gene encodes an anti-apoptotic protein that has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Details
| Type | Protein Coding |
| Official Symbol | NOL3 |
| Official Name | nucleolar protein 3 [Source:HGNC Symbol;Acc:HGNC:7869] |
| Ensembl ID | ENSG00000140939 |
| Bio databases IDs | |
| Aliases | nucleolar protein 3 |
| Synonyms | ARC, B430311C09Rik, FCM, MYC, MYOCL1, NOP, NOP30, nucleolar protein 3, nucleolar protein 3 (apoptosis repressor with CARD domain) |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NOL3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- death receptor binding
- protease binding
- caspase inhibitor activity
- calcium ion binding
- transcription activation domain
- protein domain specific binding
- protein binding
- receptor binding
- identical protein binding
- RNA binding
- Caspase recruitment domain
- cysteine protease inhibitor activity
- kinase binding
- Death Domain Superfamily of protein-protein interaction domains
- phosphatase binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- metastasis
- lung cancer
- cardiac fibrosis
- organismal death
- lung metastasis
- migraine with aura
- renal clear cell adenocarcinoma
- renal clear cell cancer
- thoracic cancer
role in cell
- cell death
- survival
- apoptosis
- proliferation
- transmembrane potential
- differentiation
- number
- growth
- cell cycle progression
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- mitochondrial fraction
- Cytoplasm
- perinuclear region
- sarcoplasmic reticulum
- Mitochondria
- cytosol
- sarcoplasm
- nucleoplasm
- nucleoli
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NOL3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- negative regulation of release of cytochrome c from mitochondria
- mRNA splice site selection
- intrinsic apoptotic signaling pathway
- blood vessel remodeling
- response to ischemia
- response to hypoxia
- release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
- cardiac muscle cell apoptotic process
- negative regulation of apoptotic process
- negative regulation of tumor necrosis factor-mediated signaling pathway
- negative regulation of extrinsic apoptotic signaling pathway
- negative regulation of muscle atrophy
- negative regulation of cardiac muscle cell apoptotic process
- negative regulation of intrinsic apoptotic signaling pathway
- response to injury involved in regulation of muscle adaptation
- protein oligomerization
Cellular Component
Where in the cell the gene product is active
- sarcoplasmic reticulum
- membrane
- mitochondrion
- cytosol
- nucleolus
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- RNA binding
- protein binding
- calcium ion binding
- death effector domain binding
- death receptor binding
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process