FADD Gene Summary [Human]
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | FADD |
| Official Name | Fas associated via death domain [Source:HGNC Symbol;Acc:HGNC:3573] |
| Ensembl ID | ENSG00000168040 |
| Bio databases IDs | |
| Aliases | Fas associated via death domain, Fas-associating protein with death domain, Fas-associating death domain-containing protein, mediator of receptor-induced toxicity, growth-inhibiting gene 3 protein |
| Synonyms | DEATH domain-containing ADAPTOR, Fas associated via death domain, GIG3, IMD90, MORT1, Mort1/FADD |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FADD often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Death effector domain
- Death domain
- death receptor binding
- granzyme B cleavage site
- death effector domain-interacting domain
- tumor necrosis factor receptor binding
- protease binding
- MORT module
- protein binding activity, bridging
- protein domain specific binding
- protein binding
- receptor binding
- identical protein binding
- phosphorylation site
- hematopoietin/interferon-class (D200-domain) cytokine receptor ligand
- binding protein
- Death Domain Superfamily of protein-protein interaction domains
- caspase-8 cleavage site
Pathways
Biological processes and signaling networks where the FADD gene in human plays a role, providing insight into its function and relevance in health or disease.
- Activation of IRF by Cytosolic Pattern Recognition Receptors
- Cellular Effects of Sildenafil (Viagra)
- Cytotoxic T Lymphocyte-mediated Apoptosis of Target Cells
- Death Receptor Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Induction of Apoptosis by HIV1
- Molecular Mechanisms of Cancer
- Myc Mediated Apoptosis Signaling
- NF-κB Signaling
- Osteoarthritis Pathway
- p38 MAPK Signaling
- Retinoic acid Mediated Apoptosis Signaling
- Role of PKR in Interferon Induction and Antiviral Response
- Role of RIG1-like Receptors in Antiviral Innate Immunity
- SAPK/JNK Signaling
- Tec Kinase Signaling
- TNFR1 Signaling
- Tumoricidal Function of Hepatic Natural Killer Cells
- TWEAK Signaling
- Type I Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- anemia
- tumorigenesis
- diabetes mellitus
- rectal adenocarcinoma
- colorectal carcinomagenesis
- rectum cancer
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- liver cancer
role in cell
- cell death
- proliferation
- differentiation
- quantity
- expression in
- apoptosis
- growth
- transmembrane potential
- development
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- autophagosomal membrane
- Nucleus
- Plasma Membrane
- cytosol
- membrane rafts
- mitotic spindle
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FADD gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of type I interferon-mediated signaling pathway
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- extrinsic apoptotic signaling pathway
- apoptotic signaling pathway
- spleen development
- lymph node development
- extrinsic apoptotic signaling pathway in absence of ligand
- positive regulation of proteolysis
- positive regulation of transcription from RNA polymerase II promoter
- induction of apoptosis via death domain receptors
- positive regulation of execution phase of apoptosis
- thymus development
- T cell homeostasis
- negative regulation of necroptosis
- behavioral response to cocaine
- motor neuron apoptotic process
- positive regulation of macrophage differentiation
- kidney development
- activation of cysteine-type endopeptidase activity
- death-inducing signaling complex assembly
- positive regulation of interferon-gamma production
- apoptotic process
- positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
- defense response to virus
- positive regulation of tumor necrosis factor production
- T cell differentiation in thymus
- positive regulation of activated T cell proliferation
- positive regulation of interleukin-8 production
- cellular response to mechanical stimulus
- positive regulation of adaptive immune response
- positive regulation of innate immune response
- innate immune response
- positive regulation of apoptotic process
- negative regulation of activation-induced cell death of T cells
- positive regulation of extrinsic apoptotic signaling pathway
- positive regulation of T cell mediated cytotoxicity
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cell body
- cytosol
- death-inducing signaling complex
- CD95 death-inducing signaling complex
- plasma membrane
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- tumor necrosis factor receptor superfamily binding
- protein binding
- signaling adaptor activity
- death effector domain binding
- tumor necrosis factor receptor binding
- death receptor binding
- protease binding
- receptor serine/threonine kinase binding
- binding, bridging