MYO1B Gene Summary [Human]
Enables ATP binding activity; actin filament binding activity; and microfilament motor activity. Involved in actin filament organization and post-Golgi vesicle-mediated transport. Located in several cellular components, including actin filament; endosome; and perinuclear region of cytoplasm. Colocalizes with trans-Golgi network membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | MYO1B |
| Official Name | myosin IB [Source:HGNC Symbol;Acc:HGNC:7596] |
| Ensembl ID | ENSG00000128641 |
| Bio databases IDs | |
| Aliases | myosin IB |
| Synonyms | LOC100909685, Mi130, MIH-L, MMIa, MMI-alpha, MMI-α, MYH-1c, MYO1B Heavy Chain, Myosin i, myosin IB, Myosin I α, Myr1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MYO1B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calmodulin binding
- Myosin and Kinesin motor domain
- ATP-binding domain
- ATP binding
- microfilament motor protein
- protein binding
- motor domain
- Myosin head (motor domain)
- actin filament binding
- Calmodulin-binding motif
- phosphatidylinositol-3,4,5-triphosphate binding
- actin binding
- phosphatidylinositol-4,5-bisphosphate binding
- IQ domain
- tail domain
- loop domain
- Unconventional myosin tail, actin- and lipid-binding
- motor protein
- Myosin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- esophageal squamous cell carcinoma
- glioblastoma
- neoplasia
- cancer
- glioblastoma cancer
- metastasis
- advanced cancer
- colorectal cancer
- diabetic nephropathy
- esophageal squamous cell cancer
role in cell
- expression in
- proliferation
- phosphorylation in
- migration
- formation
- distribution
- movement
- invasion by
- sprouting angiogenesis by
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- cell periphery
- apical compartment
- perinuclear region
- Nucleus
- Plasma Membrane
- endosomes
- lysosome
- actin filaments
- membrane ruffles
- plasma membrane projections
- trans Golgi network
- endosomal membrane
- early endosomes
- brush border
- filopodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MYO1B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- actin filament organization
- post-Golgi vesicle-mediated transport
- actin filament-based movement
- endocytosis
- actin filament bundle assembly
Cellular Component
Where in the cell the gene product is active
- myosin complex
- actin filament
- plasma membrane
- early endosome
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- apical part of cell
- brush border
- microvillus
- cytoplasm
- actin cytoskeleton
- filopodium
- endosome membrane
- trans-Golgi network membrane
- cell periphery
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- phosphatidylinositol-3,4,5-trisphosphate binding
- phosphatidylinositol-4,5-bisphosphate binding
- ATP binding
- calmodulin binding
- protein binding
- cadherin binding
- microfilament motor activity