OSBPL1A Gene Summary [Human]
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. Transcript variants derived from alternative promoter usage and/or alternative splicing exist; they encode different isoforms. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | OSBPL1A |
| Official Name | oxysterol binding protein like 1A [Source:HGNC Symbol;Acc:HGNC:16398] |
| Ensembl ID | ENSG00000141447 |
| Bio databases IDs | |
| Aliases | oxysterol binding protein like 1A |
| Synonyms | G430090F17Rik, Gm753, ORP-1, OSBPL1B, oxysterol binding protein-like 1A |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human OSBPL1A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid transporter
- Ankyrin repeats (many copies)
- cholesterol binding
- ligand-binding domain
- Ankyrin repeats (3 copies)
- PH domain
- protein binding
- Pleckstrin homology-like domain
- Oxysterol-binding protein
- Ankyrin repeat
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- psoriasis
- osteoporosis
- COVID-19
- colorectal adenoma
- colorectal adenoma formation
- systemic lupus erythematosus
- organismal death
- ischemic stroke
- colorectal adenocarcinoma
role in cell
- growth
- accumulation in
- activation in
- transformation
- vacuolation
- transcytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- cellular membrane
- Nucleus
- Plasma Membrane
- endosomes
- cytosol
- late endosomes
- perinuclear vesicles
- endocytotic vesicle
- multivesicular bodies
- organelle membrane contact site
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human OSBPL1A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid transport
- vesicle-mediated transport
- cholesterol metabolic process
- bile acid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endosome
- extracellular vesicular exosome
- perinuclear endoplasmic reticulum
- organelle membrane contact site
- late endosome
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cholesterol binding
- phospholipid binding