KITLG
KITLG Gene Summary
This gene encodes the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | KITLG |
| Official Name | KIT ligand [Source:HGNC Symbol;Acc:HGNC:6343] |
| Ensembl ID | ENSG00000049130 |
| Bio databases IDs | |
| Aliases | KIT ligand, mast cell growth factor, stem cell factor, steel factor, familial progressive hyperpigmentation 2 |
| Synonyms | blz,C-kit ligand,Clo,Con,contrasted,DCUA,DFNA69,FPH1,FPH2,FPHH,Gb,HPP1,KITL,KIT ligand,KL-1,Mast cell factor,MGF,SCF,Scf164,SCF receptor LIGAND,SF,SHEP7,Sl,SLF,STEEL FACTOR,Stem cell factor,WS2F |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- stem cell factor receptor binding
- cytoplasmic domain
- transmembrane domain
- protein binding
- Stem cell factor
- cytokine
- growth factor
Pathways
Biological processes and signaling networks where the KITLG gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- EGFR
- ATP8B2
- SIDT2
- KIT
- KLHDC10
- HMGA1
- KITLG
- SCF receptor
- ACTB
- CEBPB
disease
- precursor B-cell acute lymphoblastic leukemia
- breast cancer
- epithelial cancer
- anemia
- chronic phase chronic myeloid leukemia
- acute lymphoblastic lymphoma
- accelerated phase chronic myelogenous leukemia
- primary T acute lymphoblastic leukemia
- gastrointestinal stromal tumor
- leukemia
regulated by
- imatinib
- cholesterol
- lipopolysaccharide
- AGT
- forskolin
- TGFB1
- tetradecanoylphorbol acetate
- HMGA1
- beta-estradiol
- advanced glycation end-products
regulates
- IL1B
- IL6
- IL18
- STAT1
- STAT3
- reactive oxygen species
- ERK
- MEK
- PTGS2
- MAP2K1
role in cell
- survival
- adhesion
- chemotaxis
- phosphorylation in
- generation in
- damage in
- formation in
- migration
- proliferation
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- cellular membrane
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- nuclear speckles
- filopodia
- plasma
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the KITLG gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- germ cell programmed cell death
- male gonad development
- embryonic hemopoiesis
- positive regulation of cell proliferation
- positive regulation of Ras protein signal transduction
- Ras protein signal transduction
- cell adhesion
- extrinsic apoptotic signaling pathway in absence of ligand
- positive regulation of T cell proliferation
- response to organic cyclic compound
- positive regulation of melanocyte differentiation
- myeloid leukocyte differentiation
- hemopoietic progenitor cell differentiation
- ovarian follicle development
- positive regulation of myeloid leukocyte differentiation
- positive regulation of leukocyte migration
- neural crest cell migration
- mast cell proliferation
- T cell proliferation
- negative regulation of mast cell apoptotic process
- mast cell apoptotic process
- positive regulation of peptidyl-tyrosine phosphorylation
- positive regulation of mast cell proliferation
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
- cytoskeleton
- cytoplasm
- filopodium
- extracellular region
- plasma membrane
- lamellipodium
MOLECULAR FUNCTION
What the gene product does at the molecular level
- growth factor activity
- protein binding
- stem cell factor receptor binding
- cytokine activity