WDR45B Gene Summary [Human]
This gene encodes a member of the WIPI or SVP1 family of WD40 repeat-containing proteins. The protein contains seven WD40 repeats that are thought to fold into a beta-propeller structure that mediates protein-protein interactions, and a conserved motif for interaction with phospholipids. The human genome contains several pseudogenes of this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | WDR45B |
| Official Name | WD repeat domain 45B [Source:HGNC Symbol;Acc:HGNC:25072] |
| Ensembl ID | ENSG00000141580 |
| Bio databases IDs | |
| Aliases | WD repeat domain 45B |
| Synonyms | 0610008N23Rik, D16Bwg0193e, NEDSBAS, RGD1305141, WDR45L, WD repeat domain 45B, WIPI-3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human WDR45B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- protein binding
- phosphatidylinositol binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- lysosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human WDR45B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagic vacuole assembly
- protein localization to pre-autophagosomal structure
- peroxisome degradation
- protein lipidation
- cellular response to starvation
- mitochondrion degradation
Cellular Component
Where in the cell the gene product is active
- pre-autophagosomal structure membrane
- pre-autophagosomal structure
- cytosol
- extrinsic to membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- phosphatidylinositol-3,5-bisphosphate binding
- phosphatidylinositol-3-phosphate binding