Wdr45b Gene Summary [Mouse]
Predicted to enable TSC1-TSC2 complex binding activity; phosphatidylinositol phosphate binding activity; and protein-macromolecule adaptor activity. Predicted to be involved in autophagy of mitochondrion; cellular response to starvation; and macroautophagy. Predicted to be located in lysosome and phagophore assembly site. Predicted to be active in cytosol and phagophore assembly site membrane. Orthologous to human WDR45B (WD repeat domain 45B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wdr45b |
| Official Name | WD repeat domain 45B [Source:MGI Symbol;Acc:MGI:1914090] |
| Ensembl ID | ENSMUSG00000025173 |
| Bio databases IDs | |
| Aliases | WD repeat domain 45B |
| Synonyms | 0610008N23Rik, D16Bwg0193e, NEDSBAS, RGD1305141, WDR45L, WD repeat domain 45B, WIPI-3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wdr45b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- protein binding
- phosphatidylinositol binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- lysosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Wdr45b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagic vacuole assembly
- protein localization to pre-autophagosomal structure
- peroxisome degradation
- protein lipidation
- cellular response to starvation
- mitochondrion degradation
Cellular Component
Where in the cell the gene product is active
- pre-autophagosomal structure membrane
- pre-autophagosomal structure
- cytosol
- extrinsic to membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- phosphatidylinositol-3,5-bisphosphate binding
- phosphatidylinositol-3-phosphate binding