CACNB3 Gene Summary [Human]

This gene encodes a regulatory beta subunit of the voltage-dependent calcium channel. Beta subunits are composed of five domains, which contribute to the regulation of surface expression and gating of calcium channels and may also play a role in the regulation of transcription factors and calcium transport. [provided by RefSeq, Oct 2011]

Details

Type
Retained Intron
Official Symbol
CACNB3
Official Name
calcium voltage-gated channel auxiliary subunit beta 3 [Source:HGNC Symbol;Acc:HGNC:1403]
Ensembl ID
ENSG00000167535
Bio databases IDs NCBI: 784 Ensembl: ENSG00000167535
Aliases calcium voltage-gated channel auxiliary subunit beta 3
Synonyms Beta3, CAB3, CACH3B, CACNLB3, Calcium Channel beta3, calcium channel, voltage-dependent, beta 3 subunit, calcium channel, voltage-dependent, β 3 subunit, calcium voltage-gated channel auxiliary subunit beta 3, calcium voltage-gated channel auxiliary subunit β 3, Ca(v)beta3, Cchb3, Voltage gated calcium channel beta subunit, Voltage gated calcium channel β subunit
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CACNB3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • guanylate kinase
  • voltage-gated calcium channel
  • protein kinase binding
  • NK
  • high voltage-gated calcium channel
  • Voltage gated calcium channel subunit beta domain 4Aa N terminal
  • protein binding
  • ion channel
  • calcium channel regulator
  • Src Homology 3 domain superfamily

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
  • Parkinson disease
  • hypertension
  • arrhythmia
  • hypoglycemia
  • obesity
  • variant angina
  • ischemic cardiomyopathy
  • Wolff-Parkinson-White syndrome
  • paroxysmal supraventricular tachycardia
  • COVID-19
regulated by
  • U0126
  • MAPK9
  • MAP3K8
  • phytohemagglutinin
  • BAY K8644
  • methylmercury
  • heavy metal
  • nimodipine
  • CACNB4
  • mibefradil
regulates
role in cell
  • migration
  • expression in
  • growth
  • survival
  • function
  • transport in
  • long-term potentiation
  • depletion in
  • detachment
  • innervation

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • membrane fraction
  • Cytoplasm
  • cellular membrane
  • cytosol
  • apical membrane
  • microsomal membrane
  • cytosolic fraction

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human CACNB3 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • neuromuscular junction development
  • calcium ion transport
  • synaptic transmission
  • T cell receptor signaling pathway
  • protein localization in plasma membrane
  • calcium ion transport into cytosol

Cellular Component

Where in the cell the gene product is active
  • membrane
  • voltage-gated calcium channel complex
  • cytosol
  • synapse

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • high voltage-gated calcium channel activity
  • calcium channel regulator activity
  • voltage-gated calcium channel activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.