ST14 Gene Summary [Human]
The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ST14 |
| Official Name | ST14 transmembrane serine protease matriptase [Source:HGNC Symbol;Acc:HGNC:11344] |
| Ensembl ID | ENSG00000149418 |
| Bio databases IDs | |
| Aliases | ST14 transmembrane serine protease matriptase, epithin, matriptase, channel–activating protein 3 |
| Synonyms | ARCI11, CAP3, Epithin, HAI, Matriptase, mCAP3, MT-SP1, PRSS14, SNC19, ST14 transmembrane serine protease matriptase, suppression of tumorigenicity 14 (colon carcinoma), suppression of tumourigenicity 14 (colon carcinoma), TADG15, TMPRSS14 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ST14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Trypsin-like serine protease
- serine endopeptidase
- CUB
- trypsin
- Tryp_SPc
- serine-type peptidase
- ectodomain
- peptidase
- serine protease domain
- LDLa
- intracellular domain
- SEA domain
Pathways
Biological processes and signaling networks where the ST14 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- squamous cell cancer
- epithelial cancer
- epithelial neoplasia
- neoplasia
- dextran sodium sulfate-induced colitis
- lung cancer
- congenital ichthyosis, follicular atrophoderma, hypotrichosis and hypohidrosis
- ovarian cancer
- epidermal hyperplasia
role in cell
- expression in
- activation in
- molecular cleavage in
- migration
- proliferation
- apoptosis
- phosphorylation in
- stabilization in
- formation
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cell borders
- Extracellular Space
- cellular membrane
- plasma membrane extracellular face
- basolateral membrane
- junctional complexes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ST14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell morphogenesis involved in placental branching
- keratinocyte differentiation
- neural tube closure
- protein catabolic process
- proteolysis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- external side of plasma membrane
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase activity
- serine-type peptidase activity