URB1 Gene Summary [Human]
Enables RNA binding activity. Predicted to be involved in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in fibrillar center. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | URB1 |
| Official Name | URB1 ribosome biogenesis homolog [Source:HGNC Symbol;Acc:HGNC:17344] |
| Ensembl ID | ENSG00000142207 |
| Bio databases IDs | |
| Aliases | URB1 ribosome biogenesis homolog |
| Synonyms | 4921511H13Rik, 5730405K23Rik, AA670781, C21orf108, mKIAA0539, NPA1, RGD1304621, URB1 ribosome biogenesis 1 homolog (S. cerevisiae), URB1 ribosome biogenesis homolog |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human URB1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ribosome 60S biogenesis N-terminal
- Nucleolar pre-ribosomal-associated protein 1
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- fibrillar center
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human URB1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cellular Component
Where in the cell the gene product is active
- nucleolus
- fibrillar center
Molecular Function
What the gene product does at the molecular level
- RNA binding