FGFBP1 Gene Summary [Human]
This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4. [provided by RefSeq, Nov 2011]
Details
| Type | Protein Coding |
| Official Symbol | FGFBP1 |
| Official Name | fibroblast growth factor binding protein 1 [Source:HGNC Symbol;Acc:HGNC:19695] |
| Ensembl ID | ENSG00000137440 |
| Bio databases IDs | |
| Aliases | fibroblast growth factor binding protein 1 |
| Synonyms | Fbp, FGF-BP, fibroblast growth factor binding protein 1, HBP17 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FGFBP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FGF binding protein 1 (FGF-BP1)
- fibroblast growth factor binding
- heparin binding domain
- protein binding
- FGF binding domain
- heparin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- non-insulin-dependent diabetes mellitus
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- Alzheimer disease
- osteoarthritis
- major depression
- epidermal hyperplasia
role in cell
- phosphorylation in
- proliferation
- growth
- chemotaxis
- colony formation
- mitogenesis
- transactivation in
- sphere formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FGFBP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- negative regulation of cell proliferation
- myoblast proliferation
- cell-cell signaling
- positive regulation of myoblast proliferation
- fibroblast growth factor receptor signaling pathway
- positive regulation of fibroblast growth factor receptor signaling pathway
- positive regulation of cell migration involved in sprouting angiogenesis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- growth factor binding
- protein binding
- heparin binding
- fibroblast growth factor binding