TRIO Gene Summary [Human]
This gene encodes a large protein that functions as a GDP to GTP exchange factor. This protein promotes the reorganization of the actin cytoskeleton, thereby playing a role in cell migration and growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Details
| Type | Retained Intron |
| Official Symbol | TRIO |
| Official Name | trio Rho guanine nucleotide exchange factor [Source:HGNC Symbol;Acc:HGNC:12303] |
| Ensembl ID | ENSG00000038382 |
| Bio databases IDs | |
| Aliases | trio Rho guanine nucleotide exchange factor |
| Synonyms | 6720464I07RIK, ARHGEF23, LOC100131749, MEBAS, MRD44, MRD63, TGAT, trio Rho guanine nucleotide exchange factor, triple functional domain (PTPRF interacting) |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRIO often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain in homologues of a S
- protein serine/threonine kinase
- Protein kinase domain
- LAR interacting domain
- SH3-RhoGEF linking unstructured region
- Immunoglobulin like
- CRAL/TRIO domain
- PH domain
- Tyrosine kinase, catalytic domain
- Dbl homology domain
- Immunoglobulin V-set domain
- SPEC
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- immunoglobulin domain
- Immunoglobulin I-set domain
- enzyme binding
- protein binding
- Pleckstrin homology-like domain
- RhoGEF domain
- Src Homology 3 domain superfamily
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Spectrin repeats
- RhoGEF
- kinase domain
- Protein Kinases, catalytic domain
- Divergent CRAL/TRIO domain
- guanyl-nucleotide exchange factor
- immunoglobulin G-like domain
- Spectrin repeat
- guanine nucleotide exchange factor domain
Pathways
Biological processes and signaling networks where the TRIO gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenocarcinoma
- hepatocellular carcinoma
- autosomal dominant intellectual developmental disorder with macrocephaly type 63
- Alzheimer disease
- non-small cell lung cancer
- prostatic carcinoma
- prostate cancer
- epithelial cancer
- autosomal dominant mental retardation type 44
- hepatocellular dysplasia
role in cell
- growth
- quantity
- outgrowth
- activation in
- migration
- phosphorylation in
- synthesis in
- differentiation
- epithelial-mesenchymal transition
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- membrane fraction
- glutaminergic synapse
- postsynaptic region
- Plasma Membrane
- vesicles
- Golgi Apparatus
- cytosol
- synapse
- early endosomes
- axons
- dendrites
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRIO gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of small GTPase mediated signal transduction
- transmembrane receptor protein tyrosine phosphatase signaling pathway
- neuron projection morphogenesis
- negative regulation of fat cell differentiation
- axon guidance
Cellular Component
Where in the cell the gene product is active
- presynaptic active zone
- cytoplasm
- cytosol
- extrinsic to membrane
- cell projection
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- guanyl-nucleotide exchange factor activity
- protein serine/threonine kinase activity