SELENBP1 Gene Summary [Human]
This gene encodes a member of the selenium-binding protein family. Selenium is an essential nutrient that exhibits potent anticarcinogenic properties, and deficiency of selenium may cause certain neurologic diseases. The effects of selenium in preventing cancer and neurologic diseases may be mediated by selenium-binding proteins, and decreased expression of this gene may be associated with several types of cancer. The encoded protein may play a selenium-dependent role in ubiquitination/deubiquitination-mediated protein degradation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]
Details
| Type | Protein Coding |
| Official Symbol | SELENBP1 |
| Official Name | selenium binding protein 1 [Source:HGNC Symbol;Acc:HGNC:10719] |
| Ensembl ID | ENSG00000143416 |
| Bio databases IDs | |
| Aliases | selenium binding protein 1, methanethiol oxidase |
| Synonyms | EHMTO, HEL-S-134P, hSBP, LPSB, MTO, rSBP, SBP56, SELENBP2, selenium binding protein 1, SP56 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SELENBP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 56kDa selenium binding protein (SBP56)
- enzyme
- protein binding
- selenium binding
- methanethiol oxidase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- lung adenocarcinoma
- Alzheimer disease
- colorectal cancer
- extraoral halitosis due to methanethiol oxidase deficiency
- COVID-19
- organismal death
- lung adenocarcinoma formation
- extra oral halitosis
- androgenic alopecia
role in cell
- apoptosis
- proliferation
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- fibrillar center
- cytosol
- nucleoli
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SELENBP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein transport
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- membrane
- cytosol
- nucleolus
- fibrillar center
Molecular Function
What the gene product does at the molecular level
- methanethiol oxidase activity
- protein binding
- selenium binding