VAMP4 Gene Summary [Human]
Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. This protein may play a role in trans-Golgi network-to-endosome transport. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | VAMP4 |
| Official Name | vesicle associated membrane protein 4 [Source:HGNC Symbol;Acc:HGNC:12645] |
| Ensembl ID | ENSG00000117533 |
| Bio databases IDs | |
| Aliases | vesicle associated membrane protein 4 |
| Synonyms | D1Ertd147e, VAMP24, Vamp4 predicted, vesicle-associated membrane protein 4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human VAMP4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- dileucine internalization motif
- coiled-coil domain
- protein binding
- SNARE motif
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- non-insulin-dependent diabetes mellitus
- Alzheimer disease
- major depression
role in cell
- fusion
- activity
- response by
- release
- fusion in
- endocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- raft fractions
- membrane fraction
- glutaminergic synapse
- endocytic vesicle membrane
- cell surface
- intracellular space
- perinuclear region
- cellular membrane
- Plasma Membrane
- endosomes
- lysosome
- Golgi Apparatus
- medial face of the Golgi apparatus
- Golgi membrane
- trans face of the Golgi apparatus
- Golgi stacks
- trans Golgi network
- endosomal membrane
- early endosomes
- transport vesicles
- perinuclear vesicles
- secretory granules
- perikaryon
- clathrin-coated vesicles
- phagosomes
- immature secretory granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human VAMP4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- SNARE complex assembly
- regulation of synaptic vesicle endocytosis
- synaptic vesicle to endosome fusion
- Golgi ribbon formation
- endocytic recycling
Cellular Component
Where in the cell the gene product is active
- trans-Golgi network
- endosome
- clathrin-coated endocytic vesicle membrane
- SNARE complex
- Golgi apparatus
- Golgi membrane
- transport vesicle
- trans-Golgi network membrane
- plasma membrane
- lysosome
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding