NAT8 Gene Summary [Human]
This gene, isolated using the differential display method to detect tissue-specific genes, is specifically expressed in kidney and liver. The encoded protein shows amino acid sequence similarity to N-acetyltransferases. A similar protein in Xenopus affects cell adhesion and gastrulation movements, and may be localized in the secretory pathway. A highly similar paralog is found in a cluster with this gene. [provided by RefSeq, Sep 2008]
Details
| Type | Protein Coding |
| Official Symbol | NAT8 |
| Official Name | N-acetyltransferase 8 (putative) [Source:HGNC Symbol;Acc:HGNC:18069] |
| Ensembl ID | ENSG00000144035 |
| Bio databases IDs | |
| Aliases | N-acetyltransferase 8 (putative) |
| Synonyms | ATASE2, CCNAT, CML1, CML4, GLA, Hcml1, N-acetyltransferase 8 (putative), TSC501, TSC510 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NAT8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cysteine-S-conjugate N-acetyltransferase
- Acetyltransferase (GNAT) family
- N-acetyltransferase
- lysine N-acetyltransferase
- catalytic domain
- NAT_SF
- Acetyltransferase (GNAT) domain
- enzyme
- protein binding
- ribosomal-protein-alanine acetyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- ER-to-Golgi intermediate compartment
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NAT8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of gene expression
- glutathione metabolic process
- peptidyl-lysine N6-acetylation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- endoplasmic reticulum-Golgi intermediate compartment
- endoplasmic reticulum-Golgi intermediate compartment membrane
Molecular Function
What the gene product does at the molecular level
- cysteine-S-conjugate N-acetyltransferase activity
- lysine N-acetyltransferase activity
- protein binding
- N-acetyltransferase activity