TRIM21 Gene Summary [Human]
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TRIM21 |
| Official Name | tripartite motif containing 21 [Source:HGNC Symbol;Acc:HGNC:11312] |
| Ensembl ID | ENSG00000132109 |
| Bio databases IDs | |
| Aliases | tripartite motif containing 21, Ro/SSA 52kDa, E3 ubiquitin-protein ligase TRIM21 |
| Synonyms | RNF81, RO52, Ro/SSA, SSA, SSA1, SSA-52, tripartite motif-containing 21 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRIM21 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins
- transcription co-activator
- B-Box C-terminal domain
- SPRY domain
- RFP domain
- coiled-coil domain
- enzyme
- identical protein binding
- B30.2 domain
- associated with SPRY domains
- RING/Ubox like zinc-binding domain
- Ring finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- BRE1 E3 ubiquitin ligase
- B-box zinc finger
- RING-B-box linker domain
- SPRY-associated domain
- zinc-RING finger domain
- TPR/MLP1/MLP2-like protein
- Ezrin/radixin/moesin, alpha-helical domain
- zinc finger of C3HC4-type, RING
- ubiquitin protein ligase activity
- Ring finger domain
- protein binding
- B-box-type zinc finger superfamily
- RING-type zinc-finger
- Modified RING finger domain
- ubiquitin-protein transferase activity
- Box B domain
- RING-H2 zinc finger domain
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- glioblastoma
- glioblastoma cancer
- congenital heart block
- organismal death
- rheumatoid arthritis
- non-insulin-dependent diabetes mellitus
- insulin resistance
- osteoporosis
- disease-free survival
role in cell
- phosphorylation in
- expression in
- migration
- proliferation
- apoptosis
- growth
- autophagy by
- cell death
- production in
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- GW body
- Cytoplasm
- perinuclear region
- filamentous network
- Endoplasmic Reticulum
- granules
- cytosol
- nucleoplasm
- stress granule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRIM21 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein binding
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of cell cycle
- positive regulation of viral entry into host cell
- positive regulation of sequence-specific DNA binding transcription factor activity
- protein K27-linked ubiquitination
- negative regulation of innate immune response
- positive regulation of NF-kappaB transcription factor activity
- stress granule disassembly
- positive regulation of transcription, DNA-dependent
- pyroptosis
- protein autoubiquitination
- proteasomal protein catabolic process
- protein K48-linked ubiquitination
- negative regulation of NF-kappaB transcription factor activity
- regulation of protein localization
- response to interferon-gamma
- protein polyubiquitination
- negative regulation of protein deubiquitination
- protein monoubiquitination
- protein destabilization
- positive regulation of autophagy
- regulation of viral entry into host cell
- innate immune response
- protein K63-linked ubiquitination
- protein K6-linked ubiquitination
- protein ubiquitination
- regulation of type I interferon production
- negative regulation of viral transcription
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasmic stress granule
- cytoplasm
- cytosol
- cytoplasmic mRNA processing body
- cytoplasmic vesicle
- SCF ubiquitin ligase complex
- autophagic vacuole
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein kinase binding
- DNA binding
- identical protein binding
- zinc ion binding
- protein binding
- protein homodimerization activity
- RNA binding
- transcription coactivator activity