DDOST Gene Summary [Human]
This gene encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. The product of this gene is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | DDOST |
| Official Name | dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit [Source:HGNC Symbol;Acc:HGNC:2728] |
| Ensembl ID | ENSG00000244038 |
| Bio databases IDs | |
| Aliases | dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit, oligosaccharyltransferase subunit 48, advanced glycation end-product receptor 1 |
| Synonyms | AGE-R1, CDG1R, dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit, dolichyl-di-phosphooligosaccharide-protein glycotransferase, GATD6, LOC100504754, OKSWcl45, OST, OST48, WBP1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DDOST often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- dolichyl-diphosphooligosaccharide-protein glycotransferase
- Oligosaccharyltransferase 48 kDa subunit beta
- enzyme
- protein binding
- enzyme activator activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenoma formation
- congenital disorder of glycosylation type 1R
- aldosterone producing adrenocortical adenoma
- ocular hypertension
- infection by HIV-1
- productive infection by HIV-1
role in cell
- phosphorylation in
- expression in
- activation
- aggregation in
- N-glycosylation in
- binding in
- transactivation in
- recruitment
- oligomerization in
- epithelial-mesenchymal transition in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- intracellular membrane-bounded organelle
- cell surface
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- Mitochondria
- secretory granule membrane
- endoplasmic reticulum membrane
- Golgi membrane
- lysosome membrane
- inner nuclear membrane
- microsomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DDOST gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cytokine stimulus
- regulation of protein stability
- T cell activation
- protein glycosylation
- protein N-linked glycosylation
- protein N-linked glycosylation via asparagine
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- oligosaccharyltransferase complex
- intracellular membrane-bounded organelle
- membrane
- endoplasmic reticulum
- azurophil granule membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- enzyme activator activity