RND3 Gene Summary [Human]
This gene encodes a protein which is a member of the small GTPase protein superfamily. The encoded protein binds only GTP but has no GTPase activity, and appears to act as a negative regulator of cytoskeletal organization leading to loss of adhesion. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]
Details
| Type | Protein Coding |
| Official Symbol | RND3 |
| Official Name | Rho family GTPase 3 [Source:HGNC Symbol;Acc:HGNC:671] |
| Ensembl ID | ENSG00000115963 |
| Bio databases IDs | |
| Aliases | Rho family GTPase 3 |
| Synonyms | 2610017M01Rik, ARHE, memB, Rho8, RHOE, Rho family GTPase 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RND3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- GTPase
- enzyme
- protein binding
- Ras subfamily of RAS small GTPases
- GTP binding
- CAAX box
- small GTP-binding protein domain
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the RND3 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Actin Nucleation by ARP-WASP Complex
- Cholecystokinin/Gastrin-mediated Signaling
- CXCR4 Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- Glioblastoma Multiforme Signaling
- Glioma Invasiveness Signaling
- Gαq Signaling
- HMGB1 Signaling
- IL-8 Signaling
- ILK Signaling
- Integrin Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Regulation of Actin-based Motility by Rho
- RhoA Signaling
- RhoGDI Signaling
- Semaphorin Signaling in Neurons
- Serotonin Receptor Signaling
- Sphingosine-1-phosphate Signaling
- Tec Kinase Signaling
- Thrombin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- breast cancer
- hepatitis B virus-related hepatocellular carcinoma
- liver cancer
- obstructive hydrocephalus
- heart failure
- familial colorectal cancer
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
- T acute lymphoblastic leukemia
role in cell
- proliferation
- apoptosis
- phosphorylation in
- expression in
- accumulation in
- binding in
- migration
- signaling in
- formation
- branching
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- Plasma Membrane
- cytosol
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RND3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of actin cytoskeleton organization
- small GTPase mediated signal transduction
- signal transduction
- actin filament organization
- cell adhesion
- cell migration
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- focal adhesion
- cytosol
- Golgi membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein kinase binding
- protein binding
- GTPase activity