ATP10D Gene Summary [Human]
Enables glycosylceramide flippase activity. Predicted to be involved in phospholipid translocation. Located in endoplasmic reticulum; nucleoplasm; and plasma membrane. Is integral component of plasma membrane. Part of phospholipid-translocating ATPase complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ATP10D |
| Official Name | ATPase phospholipid transporting 10D (putative) [Source:HGNC Symbol;Acc:HGNC:13549] |
| Ensembl ID | ENSG00000145246 |
| Bio databases IDs | |
| Aliases | ATPase phospholipid transporting 10D (putative) |
| Synonyms | ATPase phospholipid transporting 10D (putative), ATPVD |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ATP10D often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid transporter
- HAD-superfamily hydrolase, subfamily IIB
- Mg2+-ATPase
- Phospholipid-translocating ATPase N-terminal
- phospholipid-translocating P-type ATPase, flippase
- sphingolipid transporter
- protein binding
- Haloacid Dehalogenase-like Hydrolases
- transporter
- Phospholipid-translocating P-type ATPase C-terminal
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- glucosylceramide (d18:1/12:0)
- N-lauroylsphingosine
- glucosylceramide
- monohexosylceramide
- ganglioside GM3 (d18:1/12:0)
- ion
role in cell
- conversion in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- Endoplasmic Reticulum
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ATP10D gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cation transport
- phospholipid translocation
- ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- endoplasmic reticulum
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATPase activity
- ATP binding
- protein binding