SCD5 Gene Summary [Human]
Stearoyl-CoA desaturase (SCD; EC 1.14.99.5) is an integral membrane protein of the endoplasmic reticulum that catalyzes the formation of monounsaturated fatty acids from saturated fatty acids. SCD may be a key regulator of energy metabolism with a role in obesity and dislipidemia. Four SCD isoforms, Scd1 through Scd4, have been identified in mouse. In contrast, only 2 SCD isoforms, SCD1 (MIM 604031) and SCD5, have been identified in human. SCD1 shares about 85% amino acid identity with all 4 mouse SCD isoforms, as well as with rat Scd1 and Scd2. In contrast, SCD5 shares limited homology with the rodent SCDs and appears to be unique to primates (Wang et al., 2005 [PubMed 15907797]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | SCD5 |
| Official Name | stearoyl-CoA desaturase 5 [Source:HGNC Symbol;Acc:HGNC:21088] |
| Ensembl ID | ENSG00000145284 |
| Bio databases IDs | |
| Aliases | stearoyl-CoA desaturase 5 |
| Synonyms | ACOD4, DFNA79, EG666417, FADS4, Gm8091, HSCD5, SCD2, SCD4, stearoyl-CoA desaturase 5, stearoyl-CoA desaturase 5 pseudogene |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SCD5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- stearoyl-CoA 9-desaturase
- Membrane-FADS-like
- oxidoreductase
- Fatty acid desaturase
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- non-insulin-dependent diabetes mellitus
- schizophrenia
- acute myeloid leukemia
- atrial premature complex
- autosomal dominant deafness type 79
- androgenic alopecia
- venous thromboembolism
- obesity
- osteochondritis dissecans
role in cell
- phosphorylation in
- proliferation
- synthesis in
- maturation
- formation in
- outgrowth
- outgrowth in
- conversion in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SCD5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- unsaturated fatty acid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- stearoyl-CoA 9-desaturase activity
- oxidoreductase activity
- metal ion binding