SEC62 Gene Summary [Human]
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC63 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | SEC62 |
| Official Name | SEC62 homolog, preprotein translocation factor [Source:HGNC Symbol;Acc:HGNC:11846] |
| Ensembl ID | ENSG00000008952 |
| Bio databases IDs | |
| Aliases | SEC62 homolog, preprotein translocation factor |
| Synonyms | 3100002M17Rik, Ab2-292, Dtrp1, Ests 92531 at, FLJ32803, HTP1, SEC62 homolog, preprotein translocation, SEC62 homolog, preprotein translocation factor, TLOC1, TP-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SEC62 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- signaling receptor activity
- protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neoplasia
- rotator cuff injury
- organismal death
- systemic juvenile idiopathic arthritis
role in cell
- expression in
- proliferation
- colony formation
- migration
- invasion by
- dipeptide repeat protein sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- cellular membrane
- ribosome
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- rough endoplasmatic reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SEC62 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cotranslational protein targeting to membrane
- posttranslational protein targeting to membrane, translocation
- posttranslational protein targeting to membrane
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- rough endoplasmic reticulum
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- signaling receptor activity