VSIG4 Gene Summary [Human]
This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Details
| Type | Protein Coding |
| Official Symbol | VSIG4 |
| Official Name | V-set and immunoglobulin domain containing 4 [Source:HGNC Symbol;Acc:HGNC:17032] |
| Ensembl ID | ENSG00000155659 |
| Bio databases IDs | |
| Aliases | V-set and immunoglobulin domain containing 4, complement receptor of the immunoglobulin superfamily |
| Synonyms | A530061A11, CRIg, V-set and immunoglobulin domain containing 4, Z39IG |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human VSIG4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Immunoglobulin V-Type
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- immunoglobulin variable region-like domain
- protein binding
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neoplasia
- atherosclerosis
- nonalcoholic fatty liver disease
- peripheral arterial disease
- epithelial cancer
- experimental autoimmune encephalomyelitis
- arthritis
- septic shock
- rheumatoid arthritis
role in cell
- killing
- expression in
- proliferation
- accumulation in
- quantity
- accumulation
- migration
- number
- function
- killing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- intracellular space
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human VSIG4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- complement activation, alternative pathway
- negative regulation of complement activation, alternative pathway
- negative regulation of interleukin-2 production
- negative regulation of macrophage activation
- negative regulation of T cell proliferation
Cellular Component
Where in the cell the gene product is active
- membrane
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- complement component C3b binding
- protein binding