IL9 Gene Summary [Human]
The protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | IL9 |
| Official Name | interleukin 9 [Source:HGNC Symbol;Acc:HGNC:6029] |
| Ensembl ID | ENSG00000145839 |
| Bio databases IDs | |
| Aliases | interleukin 9, p40 T-cell and mast cell growth factor, T-cell growth factor p40, p40 cytokine, homolog of mouse T cell and mast cell growth factor 40 |
| Synonyms | HP40, interleukin 9, P40 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IL9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- interleukin-9 receptor binding
- signal sequence hydrophobic region
- cytokine
Pathways
Biological processes and signaling networks where the IL9 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Airway Inflammation in Asthma
- Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F
- Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F
- Glucocorticoid Receptor Signaling
- Hematopoiesis from Pluripotent Stem Cells
- IL-8 Signaling
- IL-9 Signaling
- Molecular Mechanisms of Cancer
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- STAT3 Pathway
- Th1 and Th2 Activation Pathway
- Th2 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- non-Hodgkin disease
- cancer
- infection
- lymphatic neoplasia
- neoplasia
- lymphomagenesis
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
role in cell
- production in
- phosphorylation in
- proliferation
- expression in
- activation in
- quantity
- cell death
- apoptosis
- growth
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- intracellular space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IL9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of peptidyl-tyrosine phosphorylation
- positive regulation of cell growth
- inflammatory response
- B cell differentiation
- signal transduction
- immunoglobulin mediated immune response
- positive regulation of cell proliferation
- B cell proliferation
- regulation of JAK-STAT cascade
- positive regulation of interleukin-5 production
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- interleukin-9 receptor binding
- cytokine activity