TRIM41 Gene Summary [Human]
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM family is characterized by a signature motif composed of a RING finger, one or more B-box domains, and a coiled-coil region. This encoded protein may play a role in protein kinase C signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Details
| Type | Protein Coding |
| Official Symbol | TRIM41 |
| Official Name | tripartite motif containing 41 [Source:HGNC Symbol;Acc:HGNC:19013] |
| Ensembl ID | ENSG00000146063 |
| Bio databases IDs | |
| Aliases | tripartite motif containing 41, RING-finger protein that interacts with C kinase |
| Synonyms | LOC100046003, RINCK, tripartite motif-containing 41 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRIM41 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- B-box-type zinc finger superfamily
- SPRY domain
- ubiquitin protein ligase activity
- B-box zinc finger
- enzyme
- protein binding
- identical protein binding
- associated with SPRY domains
- SPRY-associated domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- oligozoospermia
- asthenozoospermia
- infection by bacteria
- infection by RNA virus
- infection by Herpesviridae
role in cell
- activation in
- apoptosis
- degradation in
- response
- meiosis
- abnormal morphology
- response by
- K48 polyubiquitination in
- retrotransposition in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent-insoluble fractions
- detergent-soluble membrane fractions
- fibrillar center
- intracellular membrane-bounded organelle
- cytosol
- nucleoplasm
- nucleoli
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRIM41 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to lipopolysaccharide
- positive regulation of type I interferon-mediated signaling pathway
- defense response to virus
- cellular response to muramyl dipeptide
- protein monoubiquitination
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nuclear body
- cytoplasm
- nucleolus
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- identical protein binding
- protein binding