PLA2G7 Gene Summary [Human]
The protein encoded by this gene is a secreted enzyme that catalyzes the degradation of platelet-activating factor to biologically inactive products. Defects in this gene are a cause of platelet-activating factor acetylhydrolase deficiency. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2009]
Details
| Type | Protein Coding |
| Official Symbol | PLA2G7 |
| Official Name | phospholipase A2 group VII [Source:HGNC Symbol;Acc:HGNC:9040] |
| Ensembl ID | ENSG00000146070 |
| Bio databases IDs | |
| Aliases | phospholipase A2 group VII |
| Synonyms | LDL-PLA2, LP-PLA2, Lyso-Paf Acetyltransferase, Paf acetylhydrolase, PAFAD, PAF-AH, phospholipase A2 group VII, phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma), Plasma paf-ah |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PLA2G7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- 1-alkyl-2-acetylglycerophosphocholine esterase
- alpha/beta hydrolases
- Platelet-activating factor acetylhydrolase, isoform II
- calcium-independent phospholipase A2
- enzyme
- protein binding
- ester bond hydrolase
Pathways
Biological processes and signaling networks where the PLA2G7 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- nonalcoholic fatty liver disease
- lymphomagenesis
- atherosclerosis
- tumorigenesis
- deficiency of platelet-activating factor acetylhydrolase
- hypersensitive reaction
- multiple sclerosis
- chronic obstructive pulmonary disease
- primary pulmonary hypertension
- preeclampsia
role in cell
- proliferation
- expression in
- apoptosis
- accumulation
- phosphorylation in
- cell viability
- migration
- production in
- accumulation in
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- intracellular space
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PLA2G7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phosphatidylcholine catabolic process
- plasma lipoprotein particle oxidation
- positive regulation of monocyte chemotaxis
- low-density lipoprotein particle remodeling
- lipid oxidation
- positive regulation of inflammatory response
- platelet activating factor metabolic process
- peptide hormone processing
Cellular Component
Where in the cell the gene product is active
- high-density lipoprotein particle
- low-density lipoprotein particle
- extracellular region
Molecular Function
What the gene product does at the molecular level
- hydrolase activity, acting on ester bonds
- calcium-independent phospholipase A2 activity
- 1-alkyl-2-acetylglycerophosphocholine esterase activity
- phospholipid binding