STK3 Gene Summary [Human]
This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Details
| Type | Processed Transcript |
| Official Symbol | STK3 |
| Official Name | serine/threonine kinase 3 [Source:HGNC Symbol;Acc:HGNC:11406] |
| Ensembl ID | ENSG00000104375 |
| Bio databases IDs | |
| Aliases | serine/threonine kinase 3, hippo (Drosophila) homolog |
| Synonyms | 0610042I06Rik, KRS1, mess1, MST, MST2, Mst3, P63krs1, serine/threonine kinase 3, Serine/Threonine Kinase 3 (STE20 Homolog), Ste20 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human STK3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Akt phosphorylation site
- catalytic domain
- ATP-binding domain
- Protein tyrosine and serine/threonine kinase
- ATP binding
- protein binding
- magnesium ion binding
- Protein kinase domain
- identical protein binding
- kinase
- protein kinase activator
- Serine/Threonine protein kinases, catalytic domain
- SARAH_SF
- Protein Kinases, catalytic domain
- C terminal SARAH domain of Mst1
- Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the STK3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- COVID-19
- organismal death
- cancer
- hypertension
- dysplasia
- breast cancer
- coronary artery disease
- Alzheimer disease
- neonatal late-onset sepsis
role in cell
- survival
- migration
- expression in
- phosphorylation in
- cell death
- stabilization in
- apoptosis
- proliferation
- quantity
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- filamentous network
- Nucleus
- centrosome
- cytosol
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human STK3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- organ growth
- positive regulation of protein binding
- regulation of MAPK cascade
- regulation of cell differentiation involved in embryonic placenta development
- positive regulation of fat cell differentiation
- JNK cascade
- positive regulation of sequence-specific DNA binding transcription factor activity
- induction of apoptosis via death domain receptors
- protein phosphorylation
- endocardium development
- protein kinase B signaling cascade
- neural tube formation
- epithelial cell proliferation
- cell differentiation involved in embryonic placenta development
- protein tetramerization
- apoptotic process
- canonical Wnt receptor signaling pathway
- protein localization to centrosome
- intracellular signal transduction
- negative regulation of organ growth
- primitive hemopoiesis
- hepatocyte apoptotic process
- negative regulation of canonical Wnt receptor signaling pathway
- central nervous system development
- protein import into nucleus
- positive regulation of JNK cascade
- positive regulation of apoptotic process
- negative regulation of epithelial cell proliferation
- hippo signaling cascade
- protein stabilization
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasm
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- identical protein binding
- protein serine/threonine kinase activator activity
- protein binding
- protein kinase activity
- protein serine/threonine kinase activity