TRAPPC14 Gene Summary [Human]
Enables alpha-tubulin binding activity. Involved in cilium assembly and regulation of cell population proliferation. Located in several cellular components, including microtubule cytoskeleton; midbody; and plasma membrane. Part of TRAPPII protein complex. Implicated in primary autosomal recessive microcephaly. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | TRAPPC14 |
| Official Name | trafficking protein particle complex 14 [Source:HGNC Symbol;Acc:HGNC:25604] |
| Ensembl ID | ENSG00000146826 |
| Bio databases IDs | |
| Aliases | trafficking protein particle complex 14, trafficking protein particle complex subunit 14 |
| Synonyms | C7orf43, MAP11, MCPH25, RGD1305455, trafficking protein particle complex 14, trafficking protein particle complex subunit 14 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRAPPC14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alpha-tubulin binding
- protein binding
- Domain of unknown function (DUF4707)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Plasma Membrane
- centrosome
- midbody
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRAPPC14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- regulation of cell proliferation
Cellular Component
Where in the cell the gene product is active
- mitotic spindle
- centriolar satellite
- intracellular membrane-bounded organelle
- midbody
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- alpha-tubulin binding