RAD23B Gene Summary [Human]
The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2011]
Details
| Type | Protein Coding |
| Official Symbol | RAD23B |
| Official Name | RAD23 homolog B, nucleotide excision repair protein [Source:HGNC Symbol;Acc:HGNC:9813] |
| Ensembl ID | ENSG00000119318 |
| Bio databases IDs | |
| Aliases | RAD23 homolog B, nucleotide excision repair protein, XP-C repair complementing protein, XP-C repair complementing complex 58 kDa |
| Synonyms | 0610007D13Rik, HHR23B, HR23B, mHR23B, P58, RAD23 homolog B, nucleotide excision repair protein |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RAD23B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- XPC-binding domain
- nucleic acid binding
- transcription factor binding
- STI1 domain
- protein binding
- ubiquitin-like domain
- sequence-specific DNA binding
- Ubiquitin family
- UV excision repair protein Rad23
- single-stranded DNA binding
- double-stranded DNA binding
- Ubl1_cv_Nsp3_N-like
- Ubiquitin homologues
- Ubiquitin-2 like Rad60 SUMO-like
Pathways
Biological processes and signaling networks where the RAD23B gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- growth failure
- blepharitis
- edema
- eyelids open at birth
- cleft lip
- prostate cancer
- motor dysfunction or movement disorder
- conjunctivitis
- rectal prolapse
role in cell
- apoptosis
- activation in
- formation
- formation in
- binding in
- abnormal morphology
- pluripotency
- recognition
- DNA damage response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RAD23B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- spermatogenesis
- nucleotide-excision repair
- embryonic organ development
- regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- XPC complex
- proteasome complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- proteasome binding
- ubiquitin binding
- polyubiquitin binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- damaged DNA binding
- single-stranded DNA binding